Myriad, based in Brighton, intends to use the Grants for the Arts money to "consolidate its recent publishing programme", as it continues to publish eight to 10 books a year, with a focus on debut novels and new work by graphic artists.
Myriad m.d. Candida Lacey said: "This is a great vote of confidence in our publishing strategy and, of course, we're completely delighted to have the support and endorsement of the Arts Council for a second term.
"We're ready to expand the imprint, seeking out, promoting and building the careers of new graphics authors in much the same way as we are working with debut writers for our fiction list."
Myriad previously received a grant from ACE in order to set up its fiction list.